Anti-Cancer Activities
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Apoptosis Induction
- Conversion of LC31 to LC311个
- P62 (SQSTM1)↓
- Beclin-1个(BC)pP38个
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Apoptosis Induction
- Annexin V/PI↑
- Cleaved PARP ↑
- Caspase 3/7个
- Bax ↑, Bcl-2↓
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UPS Induction
- MTOR, AKT
- p53, Beclin-1↓
- Caspase 3↓
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DNA damage
- yH2AX↑
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Inhibition of angiogenesis
- Capillary tube formation↓
- VEGF
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Inhibition of mutant tumor suppressor
- p53↓(RC)
-
Inhibition of metastasis
- MMP-9↓, PgE2↓
- TNF-x↓
- TIL-6, IL-8↓
- NFKB↓
- NO production↓
- PSTAT3↓
- E-cadherin↓
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Inhibition of tumor growth in vivo
-
Cell cycle arrest (BC)
- Induces Senescence (SA-B-Gal↑)
- Cyclin D1↓
- PCNA, PRB↓
- P21个
- P16,P27,с-тус ↑
Here you will find various anti-cancer activities that may help you
Although great advancements in the treatment and control of cancer progression have been achieved, the undesired side effects that are accompanied with chemotherapeutic drugs can cause severe health problems. Therefore, natural therapies, such as using plant-derived bioactive compounds with less adverse side effects, gained much interest nowadays in cancer treatment and prevention [ 1. Rhus coriaria is one of those plants with proven anticancer activities against various types of cancers. Figure summarizes the effect of Ritus coriaria against different cancers.
